| Study | Reason for exclusion |
|---|---|
| Adam 2000 | Not a trial. An introduction to a symposium |
| Anonymous 2000 | A narrative review |
| Bavdekar 1999 | Not a trial |
| Brick 1950 | Non‐randomised, no description of control treatment |
| Carapetis 1998 | Editorial emphasising on primary prevention |
| Denbow 1999 | A non‐randomised comparison of penicillin versus no prophylaxis in a pair of monozygotic twins |
| El Kholy 1980 | Not a secondary prevention trial |
| Feinstein 1964 | Comparison of penicillin with sulphadiazine |
| Gebremariam 1999 | Used historical controls |
| Ghram 1999 | A retrospective study |
| Kotby 1998 | Follow up period less than 6 months |
| Massell 1979 | comparison of penicillin with clindamycin |
| Padmavati 1987 | Used historical controls |
| Stollerman 1952 | Follow up period 2 to 10 months |
| Thamlikitkul 1992 | Pharmacokinetic study of rheumatic fever preventive regimens |
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