Kassem 1996.
| Methods | Patients were randomly assigned to either a bi‐weekly (190) or 4‐weekly (160) prophylaxis program. | |
| Participants | 360 patients 4‐20 years old. | |
| Interventions | 1. Benzathine penicillin G i.m. 2‐weekly. 2.Benzathine penicillin G i.m. 4weekly | |
| Outcomes | Streptococcal throat infections Rheumatic fever recurrence | |
| Notes | The authors do not give adequate detail on baseline characteristics but they state that the 2 prophylaxis groups had comparable age, sex ratio and were more or less matched with regard to social status, initial diagnosis and duration of rheumatic fever. Study duration was 2 years. | |
| Risk of bias | ||
| Bias | Authors' judgement | Support for judgement |
| Allocation concealment (selection bias) | Unclear risk | B ‐ Unclear |