Feinstein 1965.
| Methods | Patients were divided into 2 groups by a 'special statistical technique'. | |
| Participants | 237 patients 5‐16 years old with rheumatic fever. | |
| Interventions | Benzathine penicillin G 1.2MU i.m. monthly 2. Potassium penicillin G 400 000U 3 times a day for 10 days and patients were not on prophylactic treatment for the rest of the month. | |
| Outcomes | Streptococcal throat infections Rheumatic fever recurrence | |
| Notes | Study terminated prematurely because of marked superiority of benzathine penicillin. 17 of the 119 children initially randomised to i.m. benzathine penicillin G were later transferred to oral penicillin. Study duration was 2 years | |
| Risk of bias | ||
| Bias | Authors' judgement | Support for judgement |
| Allocation concealment (selection bias) | High risk | C ‐ Inadequate |