Table 1.
Prenatal detection rates of the fetuses with increased NT by CMA/Karyotyping and GS.
| Clinical indications | Number of cases | CMA with/without karyotyping | GS | P value | ||
|---|---|---|---|---|---|---|
| Diagnostic yield | 95% C.I. (%)# | Diagnostic yield | 95% C.I. (%)# | |||
| Isolated (increased NT with/without other soft markers) | 34 (68%) | 5/34 (14.7%) | 5.0–31.1 | 10/34 (29.4%) | 15.1–47.5 | 0.144$ |
| Syndromic (increased NT with other fetal structural malformations) | 16 (32%) | 3/16 (18.8%) | 4.0–45.6 | 6/16 (37.5%) | 15.2–64.6 | 0.433* |
| Overall | 50 | 8/50 (16%) | 7.2–29.1 | 16/50 (32%) | 19.5–46.7 | 0.061$ |
#95% confidence interval was calculated by binomial exact calculation.
$Pearson chi-square.
*Fisher’s exact test.