Extended Data Fig. 5. Genetic architecture of the pQTLs.
pQTL mapping in n = 3,301 individuals. a, Distribution of the predicted consequences of the sentinel pQTL variants compared to matched permuted null sets of variants, stratified by cis and trans. Asterisks indicate empirical enrichment using a permutation test (10,000 permuted sets of non-associated variants) at a Bonferroni-corrected significance value (P < 0.005). Bar height represents the mean proportion of variants within each class and error bars reflect one standard deviation from the mean. b, Number of proteins associated (P < 1.5 × 10−11) with each sentinel variant across the genome.