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Schematic summary of the GABAergic input to dendritic spines. Most VGLUT1-positive axon terminals originate from cortical cells (purple) and innervate spines of cortical pyramidal neurons (gray) that receive no secondary synaptic input. VGLUT2-positive axon terminals (green) originate from the thalamus and innervate larger spine heads of pyramidal cells (gray) that exhibit a second, GABAergic synaptic input (orange) in ∼10% of cases.
