Figure 3. Gene Expression Pattern of Hippo Pathway Genes.
(A) Unsupervised consensus clustering of Hippo component gene expression showing five distinct clusters, each marked by a different color in the top row bar.
(B) Sample distribution in the five clusters. Each row is a cancer type, and each column represents a cluster. The number in each cell shows the number of samples classified in the corresponding cluster; red intensity shows the percentage of samples falling into one cluster.
(C) Comparison of clustering pattern of Hippo pathway with the other nine major biological pathways. y axis shows the fraction of the second largest cluster in a given cancertype. The middle line in the box is the median, and the bottom and top of the box are the first and third quartiles, and the whiskers extend to 1.5× interquartile range of the lower quartile and the upper quartile, respectively. Only the Hippo pathway shows a statistically significant higher ratio for squamous cell-involved cancers than for non-squamous cell cancers, indicating the uniqueness of the observed clustering pattern of Hippo pathway. Wilcoxon rank-sum test p value and q are shown for significant comparisons.
See also Figure S3.