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. 2018 Jul 13;19(9):e45089. doi: 10.15252/embr.201745089

Figure EV1. Effect of application of cocaine and trains of stimuli on DA overflow in brain slices.

Figure EV1

  • A
    Single stimulus‐induced DA transients recorded in acute striatal slices by fast‐scan cyclic voltammetry following bath application of different concentrations of cocaine.
  • B, C
    Effect of cocaine on DA transients amplitude (B) and decay time constant (C) in Maged1 WT and Maged1 KO slices (mean ± s.e.m., n WT = 7, n KO = 7, Amplitude: Maged1 WT versus Maged1 KO, P = 0.24; treatment, P < 0.0001; interaction factor, P = 0.14, repeated‐measures two‐way ANOVA; Decay: Maged1 WT versus Maged1 KO, P = 0.48; treatment, P < 0.0001; interaction factor, P = 0.51, repeated‐measures two‐way ANOVA).
  • D, E
    DA overflow response to paired‐pulse stimulation (D) and trains of five pulses delivered at different frequencies (E) (Paired‐pulses: mean ± s.e.m., n WT = 11, n KO = 7, Maged1 WT versus Maged1 KO, P = 0.22; inter‐stimulus interval, P < 0.0001; interaction factor, P = 0.96, repeated‐measures two‐way ANOVA; train stimulations: mean ± SEM, n WT = 6, n KO = 5, Maged1 WT versus Maged1 KO, P = 0.0699; frequency, P = 0.0056; interaction factor, P = 0.0076, repeated‐measures two‐way ANOVA, **P = 0.0039 as compared to Maged1 WT, Sidak's post‐test).