Figure 5.
Parametric “De-activations” with Understanding. (A) Second level parametric analysis derived from 15 subjects, to show parametric modulation by understanding rating (after orthogonalization to scan-time beauty rating). One-sample t-test (df = 14) thresholded at Punc < 0.001 with an extent threshold of 10 voxels, revealed two peak “de-activations” significant (PFWE < 0.05) with familywise error correction over the whole brain volume, at (39, −52, −8) (T14 = 9.01, PFWE = 0.010) and at (30, −91, 19) (T14 = 8.05, PFWE = 0.032). A third peak at (−27, −85, 7) (T14 = 7.65, PFWE = 0.050) was just above threshold. The location of each peak is indicated by sections along the three principal axes, pinpointed with blue crosshairs and superimposed on an anatomical image which was averaged over all 15 subjects. (Note: A “de-activation” in this case relates to a negative parametric relationship; i.e., activity decreased as understanding rating increased. Overall, as can be seen in (B), these locations were significantly active above baseline). (B) A separate categorical analysis based on understanding ratings alone was used to generate contrast estimates for the four understanding categories U0, U1, U2, and U3 vs. baseline at each of the peak locations in (A).