Table 1. Effect of Lorcaserin on Lever Press Measures in Rats Trained to Respond for Food or Nicotine Reinforcement.
|
Lorcaserin (mg/kg, SC) |
|||||
|---|---|---|---|---|---|
| Vehicle | 0.3 | 0.6 | 1 | SB+1 | |
| Food maintained responding | |||||
| Total active lever responses (FR5TO20s) | 1727±206 | 1206±131 | 930±111* | 678±102* | 2024±301# |
| Total inactive lever responses (FR5TO20s) | 22±9 | 19±5 | 10±4 | 12±8 | 33±13 |
| Time-out responses (FR5TO20s) | 1025±192 | 568±124 | 367±91* | 232±77* | 1313±289# |
| Total lever presses (PR schedule) | 371±35 | 296±41 | 147±13* | 144±23* | 396±56# |
| Nicotine maintained responding | |||||
| Total active lever responses | 121±12 | 112±14 | 92±12 | 55±9* | NT |
| Total inactive lever responses | 15±4 | 13±4 | 8±2 | 6±2 | NT |
Responses are expressed as means±SEM. *P<0.05 vs vehicle; #P<0.05 vs lorcaserin 1 mg/kg (Tukey's test). NT, not tested. SB, SB-242084 (0.5 mg/kg). Food was made available under either an FR5TO20s or PR schedule. Nicotine was available under an FR5TO20s schedule, that is, identical to the equivalent food schedule (see Materials and Methods for more detail).