Figure 3.
(a) Effect of lorcaserin (0.1–1 mg/kg, SC) pretreatment against a nicotine (0.4 mg/kg, SC)-induced hyperactivity. Twelve rats, with each rat receiving all treatments according to a randomized design. *P<0.05 vs vehicle/vehicle; #P<0.05 vs vehicle/nicotine (Tukey's test). (b) Effect of SB-242084 (0.5 mg/kg, IP) against the suppressant effect of lorcaserin (0.6 mg/kg, SC) against a nicotine (0.4 mg/kg, SC)-induced hyperactivity. Thirteen rats, with each rat receiving all treatments according to a randomized design. *P<0.05 vs vehicle/cocaine treatment; #P<0.05 vs lorcaserin 1 mg/kg/nicotine treatment (Tukey's test). V1 and V2 represent vehicle-only (no nicotine) pretreatment, V1 prior to main experimental study and V2 immediately after study.